Clinical Trials

Clinical Trials

Advancing medical knowledge


Winchester District Memorial Hospital’s (WDMH) research program launched its first clinical trial to benefit patients in the fall of 2022.

This is a major advancement in our research program. Clinical trials are a key research tool for advancing medical knowledge and patient care. The knowledge gained will support the treatment we will provide in the years to come.

Clinical trials can provide positive impacts for many patients in the future, offering benefits such as new treatments or better drug options. Through rigorous testing, evidence-based trials ensure the solutions are safe and effective before they are used in clinical practice. 


WDMH has an extensive referral network to support our research:

 research referral network


Heart Disease - Pfizer

This is a three-year clinical trial looking at heart disease. Heart disease is currently the second leading cause of death within Canada, with an estimated 750,000 Canadians living with heart failure. In rural areas specifically, patients with heart failure may have a harder time accessing necessary medical services.  


WDMH is part of an international study to look at the prevalence of Transthyretin Amyloid Cardiomyopathy (ATTR-CM), which is the stiffening and thickening of the heart muscle.  ATTR-CM leads to heart muscle dysfunction, cardiomyopathy, congestive heart failure, and death. It is believed that ATTR-CM is significantly underdiagnosed.  


The primary purpose of this study is to assess how common ATTR-CM is among patients with heart failure, to estimate the global prevalence of ATTR-CM. Knowing how prevalent the disease is will allow for further investigation into early diagnosis and treatment.


COVID Treatment - Pfizer

In a healthy individual, the immune system works to clear the body of any viral or bacterial infections. However, certain conditions, medications, or diseases can cause the immune system to become compromised, or suppressed.

Immunocompromised patients with COVID-19 are at a higher risk of developing severe infections, due to a decreased immune response, a higher viral load within the body, and the increased potential for treatment-resistant strains to develop. This increased potential for the emergence of new variants puts the general population at risk.

Paxlovid is an approved treatment for mild-moderate COVID symptoms in adults and pediatric (12+) patients, but for immunocompromised patients, the current 5-day treatment protocol may not be long enough to fully clear the virus from the body. This study will explore the efficacy and safety of various treatment lengths, to determine the most effective and safe protocol for use within immunocompromised populations. 


COVID Relapse  - Pfizer


Paxlovid has been shown to be a safe and effective treatment for mild to moderate COVID-19. However, in some people whose immune systems are compromised, the current 5-day treatment of Paxlovid might not be long enough to fully clear the virus from their body.


Immunocompromised patients are at a higher risk for complications and severe symptoms and are also at a higher risk for developing treatment-resistant strains. Some immunocompromised patients are experiencing a “rebound” in Covid-19 symptoms, where their symptoms return after they have recovered and tested negative. 

This study is a double-blind study, to assess the safety and efficacy of a second, 5-day treatment course of Paxlovid.  It will focus on patients over the age of 12, who have completed their initial treatment course but have had a reoccurrence of symptoms within two weeks. 


E-Coli Vaccine Trial - Janssen


E-Coli is a very common bacteria, and is the number one cause of Urinary Tract Infections (UTIs). Left untreated, and especially in older adults, this bacteria can progress further into the internal organs and blood stream, leading to systemic bacterial infection. Once the bacteria travels into the bloodstream and internal organs, it requires the use of complex IV antibiotics to treat. However, E-Coli bacteria is becoming highly resistant to most commonly-used antibiotics. This antibiotic resistance can lead to treatment failure, increased hospitalization, morbidity, and mortality rates, and increased healthcare costs.

This study will focus on patients 65+ with recurrent UTIs, who will receive an E-Coli vaccine, to determine whether the vaccine will help to provide protection from E-Coli bacteria, and prevent the systemic bacterial infections that can occur. The development of an E-Coli vaccine will prevent over-use of antibiotics, which in turn will minimize the development of antibiotic resistance.


Chronic Obstructive Pulmonary Disease (COPD) - AstraZeneca


Chronic obstructive pulmonary disease (COPD) refers to two conditions in which your airways become constricted, or “blocked”: obstructive chronic bronchitis, and emphysema. With bronchitis, your airways become inflamed and filled with a thick, sticky mucus. In cases of emphysema, the air sacs within your lungs are unable to effectively exchange oxygen and carbon dioxide. These conditions can occur separately or together, and can cause many debilitating symptoms.  


Interleukin-33 is a protein which is expressed by the cells in your lungs, in response to cell injury (eg. respiratory viral infections). This protein increases mucus production, inflammation, and increases the number of cells capable of producing mucus. In patients with COPD, this protein expression is increased. This leads to mucus induced airway obstruction, and increased risk of COPD exacerbations. MEDI3506 is a treatment that binds to these proteins, and blocks their ability to work. By blocking the signalling of this protein, it has the potential to disrupt the cycle of inflammatory structural damage in lungs of patients with COPD, and thereby provide symptom relief and management for patients with COPD. 


The purpose of this Phase III study is to evaluate the efficacy and safety of MEDI3506 given subcutaneously every 8 weeks and every 4 weeks, in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. 


Atrial Fibrillation - Incarda 


Atrial fibrillation (AFib) occurs when the upper two chambers of your heart beat irregularly, or inefficiently, which means that blood is unable to flow into the lower chambers of your heart as well as it should. AFib is the most common cardiac arrhythmia seen in clinical settings, with an estimated global prevalence of 33.5 million people. In patients with AFib, systemic blood clots, unstable blood pressure, decreased blood flow, and ventricular arrhythmias contribute to a significant increase in morbidity, mortality, and frequent hospitalizations. 


This study is a double-blind study, designed to assess the efficacy of flecainide acetate inhalation in converting atrial fibrillation to a normal heart rhythm, in patients with recent-onset, symptomatic, newly diagnosed or paroxysmal AFib. It will also evaluate the effects of flecainide acetate inhalation solution and placebo on the time to conversion of AFib to normal heart rhythm, AFib-related symptoms, hospitalizations, AFib-related interventions, and the time to discharge. 




If you would like to participate in any of our future research studies or would like any information on our current projects, please contact our research department at